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Biological activity for aicar. Aicar is a cell-permeable, allosteric activator of amp-activated protein kinase (ampk). Specifically, aicar inhibits, but compound c promotes, ca2+-induced t cell death in an ampk-dependent manner. In contrast, our data also. 5-aminoimidazole-4-carboxamide ribonucleoside (aicar) has been one of the most commonly used pharmacological modulators of ampk activity. Aicar (5-aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside), an amp-activated protein kinase (ampk) agonist, has demonstrated antitumor. Purpose: : amp-activated protein kinase (ampk) plays a key role in the regulation of energy homeostasis in various organs including muscles and liver. Aicar is an analog of adenosine monophosphate (amp) that is capable of stimulating amp-dependent protein kinase (ampk) activity. The drug has also been. It was also reported that stimulation with the ampk activator 5-aminoimidazole-4-carboxamide ribonucleoside. (aicar) suppresses hepatic pepck-c expression and. 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