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The recommended dose of zytiga is 1,000 mg (two 500 mg tablets or four 250 mg tablets) orally once daily with prednisone 5 mg orally twice daily. The combination of abiraterone with prednisone, 5 mg, twice daily, appears to have the best safety profile in men with mcrpc. The efficacy of the 5 mg dose was not different from placebo. Daily doses of nsaids and oral corticosteroids (≤10 mg prednisolone or the corticosteroid. Prednisone or prednisolone 1 mg/kg (max 30 mg) po x 1 dose, then 1 mg/kg po twice daily x 5 days. Multiple oral dose (greenberg, kerby, & roosevelt, 2008)
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