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Current guidelines state that steroids are not harmful in pregnancy or breastfeeding. Single steroid injections shouldn’t affect fertility, pregnancy or breastfeeding and can be useful treatments in these situations. If, however, you’re pregnant or breastfeeding you should discuss it with your doctor before having a steroid injection. Our editors will review what you’ve submitted and determine whether to revise the article. Steroids are important in biology, chemistry, and medicine. The steroid group includes all the sex hormones, adrenal cortical hormones, bile acids, and sterols of vertebrates, as well as the molting hormones of insects and many other physiologically active substances of animals and plants. Among the synthetic steroids of therapeutic value are a large number of anti-inflammatory agents, anabolic (growth-stimulating) agents, and oral contraceptives. Different categories of steroids are frequently distinguished from each other by names that relate to their biological source’e. Steroids vary from one another in the nature of attached groups, the position of the groups, and the configuration of the steroid nucleus (or gonane). Small modifications in the molecular structures of steroids can produce remarkable differences in their biological activities. This article covers the history, chemistry, biological significance, and basic pharmacology of steroids. For more information about the physiological relevance and the pharmacological applications of steroids, see human endocrine system, endocrine system, and drug. The first therapeutic use of steroids occurred in the 18th century when English physician William Withering used digitalis, a compound extracted from the leaves of the common foxglove ( Digitalis purpurea ), to treat edema. Studies of steroids commenced in the early 19th century with investigations of the unsaponifiable (i. 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