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This is unseen with the other two major aromatase inhibitors (Arimidex and Letrozole), which are non-suicidal aromatase inhibitors that are only bound to the aromatase enzyme for limited time periods before the aromatase inhibitors unbind and become metabolized. If a non-suicidal aromatase inhibitor is halted too abruptly, the circulating inhibited aromatase enzymes that have not been metabolized out of the body will then become free again, and begin aromatizing androgens into Estrogens at an often rapid rate. This is not the case with Aromasin. Exemestane was initially designed by Pharmacia & Upjohn for the treatment of female breast cancer patients, specifically post-menopausal patients, and it is used as an adjunct therapy when other first-line treatments for breast cancer (such as Nolvadex) have failed. 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