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Certainly a combination of whey and casein may offer the anabolic and anti-catabolic benefits of both proteins, as well as, all the bioactive peptides of bothproteins – both whey and casein. This would seem to be a major advantage when considering both types as an alternative to a ketogenic diet, which I personally use for the treatment of hypothyroidism.
To test whether whey and casein provided the same performance benefits, we decided to test a number of athletes – from an elite distance runner to weight lifters, cyclists and cross trainers. On average, athletes ingested 7.2 grams of whey protein per day, which was 2.5 grams (0.1 ounce) for a 40-kilogram (100 pound) man.
To check for blood glucose (blood sugar), we randomly divided the group randomly into four groups of three. One group ingested whey on a day when their blood glucose was normal (glucose concentration was between 120 and 130 mg/dl). Another group ingested whey on a day when their glucose concentration exceeded 140 mg/dl (high blood sugar). A third group ingested whey on a day with their glucose level at or above 160 mg/dl (medium insulin action). The fourth group consumed whey, a placebo or placebo and a placebo (control) on a day with their glucose level at or above 100 mg/dl (high insulin action). Blood glucose concentrations were measured daily throughout the study as a means to monitor adherence and to detect any side effects from the use of whey.
We did not see any changes in blood glucose in the whey group compared to the control group. A significant time by group effect was observed when comparing the highest level of whey supplementation to placebo group. The difference between groups of whey supplementation was statistically significant for both glucose and blood glucose and also for fat-free mass (FFM). The differences between groups of whey supplementation were significant at the same glucose and plasma glucose concentrations and also for fat-free mass (FFM) and FFM/FM ratio which are also indicators for muscle protein synthesis.
The highest level of whey supplementation performed as a better than placebo for glucose, FFM, and blood glucose, and no additional benefits were seen for glucose, FFM, or plasma glucose compared to placebo, while the lowest levels of whey supplementation performed as a poor than placebo for most parameters of exercise performance and FFM/FM ratio, including muscle protein synthesis and insulin sensitivity. The overall difference between the lowest and highest levels of whey supplementation was statistically significant. The whey group supplemented with the least amount of whey supplementation had lower levels
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