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At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary Follicle Stimulating Hormone (FSH). There is a lack of substantial evidence that androgens are effective in fractures, surgery, convalescence, and functional uterine bleeding. Primary hypogonadism (congenital or acquired) ‘ Testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, or orchidectomy. Hypogonadotropic hypogonadism (congenital or acquired) ‘ Idiopathic gonadotropin or luteinizing hormone-releasing hormone (LHRH) deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation. Prolonged androgen treatment will be required to maintain sexual characteristics in these and other males who develop testosterone deficiency after puberty. Delayed puberty ‘ (Testosterone Enanthate Injection) may be used to stimulate puberty in carefully selected males with clearly delayed puberty. 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