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When the ligand binds to the internal receptor, a conformational change is triggered that exposes a DNA-binding site on the protein, ostarine mk-2866 cycle. The ligand-receptor complex moves into the nucleus, then binds to specific regulatory regions of the chromosomal DNA and promotes the initiation of transcription (Figure 9. Lipophilic steroid hormones are largely bound to plasma proteins for their extracellular transport, ostarine mk-2866 drug test. For cortisol this is cortisol-binding globulin (CBG), and for sex steroids this is sex steroid-binding β-globulin (SBBG). So, this binding either activates or releases the associated proteins of chromatin to modify the transcription. In the end, the steroid hormone determines the amount of a particular protein in the cell, ostarine mk-2866 ireland. Hormones are molecules produced and secreted by endocrine glands in the body, ostarine mk-2866 como tomar. 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