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Gonadotropik hormonlarin (FSH,LH) uyarilmasi over foliküllerinin olgunlasmasini ve endokrin aktivitesini stimüle eder. Bunu takiben korpus luteum gelisir ve fonksiyonel hale gelir. FARMAKOKINETIK ÖZELLIKLERI: Klomen, oral yolla alindiktan sonra tam olarak absorbe olur. Plazma yarilanma süresi 5 gündür. Karacigerde metabolize olan Klomifen temel olarak feçes ile atilir. ENDIKASYONLARI : Klomen ; 1- Hipotalamus-hipofiz-over aksi normal olan Anovülar, Infertil kadinlarda * Ovülasyonun saglanmasi * Luteal faz disfonksiyonunun düzeltilmesi 2- In-vitro Fertilizasyon (Tüp bebek) isleminde * Multipl folikül gelisiminin temini 3- Oligospermik Infertil erkeklerde (Primer,hipotalamus,hipofiz ve testis yetersizligiolmayan) sperm sayisinin artirilmasi amaciyla kullanilir. KONTRENDIKASYONLARI : Asagidaki durumlarda klomifen tedavisi kontrendikedir : 1- Klomifen sitrata asiri duyarliligi olanlar, 2- Gebelik : Gebelikte veya gebelikten süphelenilen durumlarda kullanilmamali, gebelik olusursa tedavi kesilmelidir. Ovaryen Hipersitümülasyon Sendromu (OHSS) : Klomifen tedavisi sirasinda nadiren görülecegi bildirilmistir. OHSS’ nin erken bulgulari; ciddi karin agrisi, bulanti, kusma, diyare gibi semptomlar olup, bazen ciddi over büyümesi, dispne, oligüri, hipovolemi, asit, plevral effüzyon gibi ciddi rahatsizliklara neden olabilir. Bu nedenle bu tip yakinmalari olan hastalar yakin takip edilmelidir. Klomifen Tedavisi : Tedaviye baslamadan önce tam pelvik muayene yapilmali over kisti, endometrial kanser gibi ihtimaller ekarte edilmeli ve her kürden önce muayene tekrarlanmalidir. Over kisti (Polikistik over hariç) olan hastalarda, overin büyümesine neden olabileceginden kullanilmamalidir. Klomifen tedavisi sirasinda gelisebilecek anormal over genislemesini önlemek için tedaviye, cevabin alinabilecegi en düsük dozla baslanmalidir. Tedavi sirasinda over büyümesi olusursa overler normale dönene kadar tedaviye ara verilmelidir. Tedavi sirasinda olusan büyüme ve kistler tedavinin kesilmesiyle birkaç gün veya birkaç haftada spontan olarak geriler bu nedenle güçlü bir endikasyon olmadikça laparoskopi’den kaçinilmalidir. Çogul Gebelik: Klomifen tedavisi sirasinda % 90 tek ve % 10 oraninda ikiz gebelik olusabilecegi bildirilmistir. Üçüz veya daha fazla sayida gebelik orani % 1’den azdir. Bu durum tedaviye baslanmadan önce hasta ve esine anlatilmalidir. Hamilelikte Kullanimi : Hamilelikte kullanilmamalidir. YAN ETKILER / ADVERS ETKILER : Tavsiye edilen dozlarda görülebilecek yan etkiler önemsizdir ve tedaviyi nadiren etkiler. Uzun süreli yüksek doz uygulamalarinda yan etkilerde artis olabilir. En çok görülen yan etkiler : Vazomotor kizarmalar, karin bölgesinde huzursuzluk, anormal uterin kanamalar, over hipertrofisi, gögüslerde gerginlik ve dolgunluk, görmede bulanikliktir. Seyrek olarak da ; Bulanti, kusma, gerginlik,uyku bozuklugu, bas dönmesi, poliüri, ürtiker görülebilir, letrasan 2.5 mg antiestrogens $90.00 femara. KULLANIM SEKLI ve DOZU : Kadinlarda : Ilk kür için tavsiye edilen doz 5 gün süreyle günde 50 mg’dir(1 tablet). Progestin kullanimi ile saglanan bir kanama veya spontan adet kanamasi olan hastalarda tedaviye siklusun 5.
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Effects of androgens are most evident during puberty, when they induce deep. Anabolic steroids are drugs that help the growth and repair of muscle tissue. Testosterone enanthate is a slow-acting injectable form of the androgen. 2015 — for men who use anabolic-androgenic steroid (aas) a unique condition known as anabolic steroid-induced hypogonadism (asih) becomes a real. 2009 · цитируется: 86 — anabolic steroid-induced hypogonadism (asih). Anabolic–androgenic steroids (aas) are a class of compounds that include any drug or hormonal substance,. Testosterone and impaired spermatogenesis, was induced in the patient. The use of anabolic androgenic steroids has not been traditionally discussed in mainstream medicine. With the increased diagnosis of hypogonadism a. 2014 · цитируется: 166 — complete endocrine and metabolic assessment should be conducted. Management strategies for anabolic steroid-associated hypogonadism (asih) include judicious use. Anabolic-androgenic steroid (aas), both prescription and. — the anabolic–androgenic steroids (aas) are clinically used as an androgen replacement, in hypogonadism treatment, to induce puberty,. Автор: єв лучицький — the use of androgens and/or anabolic steroids is common among professional athletes who use them to increase sports performance and bodybuilding,. 2014 · цитируется: 166 — additionally, for men who have previously used aas, a unique condition known as anabolic steroid–induced hypogonadism (asih) becomes a real concern. 2017 — 3. 4 male hypogonadism due to defects of androgen target organs. 5 anabolic steroid–induced hypogonadism. Cases of hypogonadism in young men are related to. Anabolic steroid induced hypogonadism treated with human. Genomic and non-genomic mechanisms of aas induced skeletal muscle undefined Growth hormone is an excellent aid in the recovery of the body after injuries and diseases, helps to rejuvenate the body and also slows down the aging process. Gonadotropin has almost the same effect, which can be compared with human Chorionic gonadotropin, anabolic androgenic steroid-induced hepatotoxicity
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