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The NBS was set up by the Department for Health Evidence, the Department of Laboratory Medicine and the Department of Internal Medicine of the Radboud university medical center (Radboudumc) in Nijmegen in collaboration with the municipality of Nijmegen and the community health service of Nijmegen. At a later stage, the Department of Human Genetics of the Radboudumc joined the NBS project team. Approval to conduct the NBS was obtained from the Radboud university medical center Institutional Review Board. All participants gave written informed consent. Who is in the cohort? The logistic set-up of the NBS was tested in a pilot study performed between November 2001 and February 2002. Via the population registers of the municipality of Nijmegen, the names and addresses of 650 males and females aged 18 years and older were obtained. 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