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PLoS One 5, e11479 (2010). Infect Immun 68, 2470’2474 (2000). Protein toxins: intracellular trafficking for targeted therapy. Gene Ther 12, 1360’1368 (2005). The KDEL retrieval system is exploited by Pseudomonas exotoxin A, but not by Shiga-like toxin-1, during retrograde transport from the Golgi complex to the endoplasmic reticulum. J Cell Sci 112 (Pt 4) 467’475 (1999). Herpes simplex virus type 1 capsids transit by the trans-Golgi network, where viral glycoproteins accumulate independently of capsid egress. Journal of virology 79, 8847’8860 (2005). Human cytomegalovirus entry into dendritic cells occurs via a macropinocytosis-like pathway in a pH-independent and cholesterol-dependent manner. PLoS One 7, e34795 (2012). Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein. PLoS Pathog 9, e1003309 (2013). Springer: Basel AG, (2012). High-performance liquid chromatographic method for determination of amodiaquine, chloroquine and their monodesethyl metabolites in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci 783, 473’480 (2003). Field-adapted sampling of whole blood to determine the levels of amodiaquine and its metabolite in children with uncomplicated malaria treated with amodiaquine plus artesunate combination. Malaria journal 8, 52 (2009). Pharmacokinetics of amodiaquine and desethylamodiaquine in pregnant and postpartum women with Plasmodium vivax malaria. Antimicrob Agents Chemother 55, 4338’4342 (2011). EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin. Proc Natl Acad Sci USA 101, 17246’17251 (2004). Stephen Leppla of the NIAID for a kind gift of FP59 toxin and Dr. Robert Peterson for assistance with the NMR spectroscopy. We acknowledge the Ralph M, fake steroid companies. Parson’s Foundation award awarded to K.
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