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PMID: 18926742 DOI: 10. 021 Abstract Clenbuterol is a beta (2)-agonist and potent selective bronchodilator that is used to treat bronchospasm in the horse. The drug is normally administered to horses orally as a syrup formulation. Ed Robinson points out that the action of beta-2-adrenoceptor agonists (including albuterol, pirbuterol, terbutaline and salmeterol) are not re- stricted to smooth muscle,t This class of drugs also effects epithelium, in- flammatory cells, and the vasculature. Abstract Objective—To determine whether prolonged administration of clenbuterol results in tachyphylaxis, specifically regarding its bronchoprotective properties and effect on sweating in horses. Animals—8 Thoroughbreds with inflammatory airway disease. Procedures—In a crossover design, horses received clenbuterol (0. Veterinarians should be warned that clenbuterol is often abused in humans for the purpose of muscle building and weight loss. Subsequently, high doses in humans may cause cardiac toxicity, such as arrhythmias. Because clenbuterol is a beta-agonist, other adrenergic drugs potentiate the action. In some countries, this medicine may only be approved for veterinary use. INN ATC (Anatomical Therapeutic Chemical Classification) R03AC14,R03CC13 CAS registry number (Chemical Abstracts Service) 0037148-27-9 Chemical Formula C12-H18-Cl2-N2-O Molecular Weight 277 Therapeutic Categories Bronchodilator β₂-Sympathomimetic agent. This syrup, produced by Boehringer Ingelheim Vetmedica Inc. , contains a small amount of clenbuterol. Under the Animal Medicinal Drug Use Clarification Act, compounding is permitted only under limited circumstances David Smith, clenbuterol veterinary.
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