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The men were randomised to Weight Watchers weight loss programme plus placebo versus the same weight loss programme plus testosteronedosing. They were followed for six months.
In the Weight Watchers programme, 25 overweight men were randomly assigned to receive either 250 mg of testosterone or placebo each week for five days or to receive 300 mg of testosterone each week for five days or the same dose plus 300 mg of testosterone for up to 12 weeks.
They were then assessed for their metabolic syndrome, blood pressure, and their blood levels of total testosterone by using a modified metabolic syndrome index (MSI).
Treatments
The control group and the treatment group each received 25 mg of testosterone once a week for five days.
The testosterone group received 300 mg of testosterone twice a week for five days and the placebo group was given 300 mg of testosterone twice a week for five days.
Participants began their programme on the first day of the week and completed the maintenance phase (the last week of the treatment period) at the end of a 12-month period.
Testosterone was supplied in a 100 g tablet that contained 200 mg of testosterone hydrochloride as a capsule, and there were two doses taken each day with drinks included.
Results
Body weight did not change significantly between the groups as the placebo group also lost less, although overall fat and lean mass were lower than in the testosterone group.
Men who reported a metabolic syndrome score of greater than or equal to 4 on the modified MSI were included in the treatment group but there was not any difference in this score between the groups.
The men in the testosterone group reported that they did not experience fatigue and did not develop depression or anxiety over the 12-month maintenance period.
There was a statistically significant decrease in heart rate, blood pressure, blood lipid levels and glucose after maintenance, and there was a significant increase in lean mass.
Lowers for both cholesterol and high-density lipoprotein cholesterol (HDL) after maintenance were seen in the testosterone group, but there was no significant change in blood glucose.
A reduced rate of weight gain was also noted in the testosterone group, though there were no differences between the groups in terms of body mass index.
The number of women presenting with pre-existing metabolic syndrome during the first year after therapy was no different between the two groups, however the men in the testosterone group reported less depressive symptoms and a higher blood pressure at baseline.
Weight loss
Weight loss varied from one trial to the next. Three of the men who had lost a large amount of
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