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Ghrelin itself so far as I know has not been used as a performance-enhancing drug. In contrast, experience with GHRP’s is quite extensive. GHRP-6 in particular has in many cases been effective in treating tendonitis, which may well be due to its activity at the ghrelin receptor. Broadly speaking, it’s long been a widespread view that fasting can in many instances provide healthful effects beyond simple fat loss. It’s speculative to say that increased ghrelin levels must be a major cause of such effect (if granting the effect), but it’s entirely consistent with the scientific literature that such elevation of ghrelin levels may have health benefits. Appropriate-dosed and cycled GHRP use may at least partially provide such benefits, particularly with regard to anti-inflammatory and healing effect. There are indications in the literature of ghrelin acting to promote fat-storage, but this appears to be tissue-specific, for example in the liver. In bodybuilding, by no means has any such effect been apparent with GHRP-6. Instead, GHRP-6 has been effective as a cutting drug, provided that food intake is controlled. Because some GHRP’s are equally effective as others in increasing GH but differ in effect on hunger or ACTH stimulation, it seems likely that there may be differences in ghrelin receptors between different tissues, or differences in function (for example with cofactors. Factors decreasing efficacy of GHRP-6. For increasing GH levels, GHRP-6 is less effective in the presence of high blood glucose levels or high somatostatin levels, which result from high IGF-1 levels. For this reason, for best effect GHRP-6 should be taken while blood sugar is relatively low, for example about 30-60 minutes before a meal. GHRP-6 will have reduced effect if GH is being taken by injection, because GH increases IGF-1. 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