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The men were randomised to Weight Watchers weight loss programme plus placebo versus the same weight loss programme plus testosteroneand placebo plus placebo plus testosterone. They were tested for weight reduction and fat reduction in a group dieting for at least 12 months. The outcome variable in study 2 was mean weight and fat loss as assessed by anthropometric measurements.
Results
At baseline the mean age was 41.1 (8.0) years, and the BMI was 23.7 (5.5) kg/m2. No significant group differences were found for the main weight loss measures (body mass index, waist circumference) between the weight loss treatment arms. At post-baseline testing, the men on Weight Watchers had the lowest mean weight loss (5.0 kg) relative to the men on placebo (5.9 kg). For body weight, Body Mass Index (BMI) and waist circumference were not associated with weight and fat loss measures after adjustment for potential confounders [adjusted ratio of weight loss to BMI (weight minus waist circumference)/BMI = 0.93 (p=0.19); adjusted ratio of weight loss to waist circumference (weight minus circumference)/BMI = 0.94 (p=0.24); adjusted ratio of weight loss to total body weight (weight minus total body length)/BMI = 0.75 (p=0.16)].
Intervention and follow-up characteristics are shown in Table 1. After 12 months, the placebo group had significantly lower body weight (3.3 kg), BMI (BMI=24.2, mean=25.1) and waist circumference (BMI=21.0, mean=19.3). There was no difference between the weight change in men on Weight Watchers and men on testosterone or placebo.
There were no significant differences between the men on Weight Watchers and the men on testosterone or placebo concerning age, sex, body mass index, waist circumference, body weight or fat reduction during weight loss (Table 2). In addition, there was no significant interaction between weight loss and testosterone, weight loss and BMI and weight loss and serum total testosterone and total testosterone, or sex. Body weight loss was not significantly different between the men on Weight Watchers and the men on testosterone or placebo, after adjustment for body weight and all other potential confounders (Table 3).
Conclusion
The results from this study suggest that long-term Weight Watchers weight control program is significantly more effective and more effective than an exercise intervention in reducing weight and increasing fat loss in men with obesity.
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