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The Sertoli cell also produces a number of growth factors, such as IGF-1, basic fibroblast growth factor, activin A, transforming growth factor-α (TGF-α) and TGF-β, interleukin 1α (IL-1α) and IL-6, stem cell factor (SCF, the KIT ligand), glial cell–derived neurotrophic factor (GDNF), and polyamines (putrescine, spermine, and spermidine), that act both as paracrine regulators of stem cell renewal, germ cell development, and Leydig cell and peritubular myoid cell function and as autocrine regulators, anabolic steroids jaw pain.
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